Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FOXO3 / stress resistance / longevity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| FOXO3 | participates_in | gene | 0.36 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| FOXO3-Longevity Pathway Epigenetic Reprogramming | 0.386 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| Fifteen-minute consultation: Therapeutic hypothermia for infants with hypoxic is [PMID:31292147] | Cawley P, Chakkarapani E | Arch Dis Child Educ Pract Ed | 2020 | 1 |
| Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve reg [PMID:30135423] | Sahoo PK, Lee SJ, Jaiswal PB, Alber S, K | Nat Commun | 2018 | 1 |
| EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. [PMID:28814570] | Yang C, Wu J, de Heus C, Grigoriev I, Li | J Cell Biol | 2017 | 1 |
| c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Dif [PMID:26694615] | Ishibashi R, Kozuki S, Kamakura S, Sumim | J Biol Chem | 2016 | 1 |
| DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperate [PMID:24652652] | Polato F, Rusconi P, Zangrossi S, Morell | J Natl Cancer Inst | 2014 | 1 |
| IRF4 addiction in multiple myeloma. [PMID:18568025] | Shaffer AL, Emre NC, Lamy L, Ngo VN, Wri | Nature | 2008 | 1 |
| Guishen-erxian decoction can improve ovarian function in rats with premature ova [PMID:40931880] | Zhong H, He Y, Wang W, Liu Y, Chen D et | Histol Histopathol | 2026 | 0 |
| Metabolic surgery mitigates early kidney injury in obese youth with diabetes by [PMID:41665972] | Naik AS, Alakwaa FM, Nair V, McCown PJ, | J Clin Invest | 2026 | 0 |
| FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by [PMID:41860561] | Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ e | Aging Cell | 2026 | 0 |
| Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activat [PMID:41891498] | Xu J, Wan W, Mu H, Gong S, Liu Y et al. | J Biochem Mol Toxicol | 2026 | 0 |
| IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macr [PMID:41918304] | Ma Y, Gan S, Zheng Y, Kang X, Zhu S | Korean J Pain | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Genome-wide association study and pathway analysis of healthy aging in Super Sen [PMID:41964836] | Hoque R, Leach S, Brooks-Wilson A | Geroscience | 2026 | 0 |
| Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoc [PMID:40106360] | Zhang W, Li W, Du J, Yang C, Yu L, Yang | Proceedings of the National Ac | 2025 | 0 |
| Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic [PMID:40634825] | Wei P, Zhang X, Yan C, Sun S, Chen Z, Li | Biogerontology | 2025 | 0 |
| The multifaceted impact of physical exercise on FoxO signaling pathways. [PMID:40861274] | Liu W, Meng P, Li Z, Shen Y, Meng X, Jin | Frontiers in cell and developm | 2025 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| Banxia Xiexin Decoction Prevents HT22 Cells from High Glucose-induced Neurotoxic [PMID:37608672] | ["Shi Y", "Sheng P", "Guo M", "Chen K", | Current computer-aided drug de | 2024 | 0 |
| Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. [PMID:36252111] | Zhu D, Liu S, Huang K, Wang Z, Hu S, Li | Circulation research | 2022 | 0 |